Peter Nigrovic M.D.

Dr. Nigrovic is the principal investigator of laboratory and an Associate Professor of Medicine at Harvard Medical School. Dr. Nigrovic received a B.A. in philosophy from Amherst College, including a year of study at Corpus Christi College, Oxford, followed by his medical degree at Harvard Medical School.  He completed med/peds residency in the Harvard combined program and med/peds rheumatology fellowship at Boston Children’s Hospital and the Brigham and Women’s Hospital, where he trained with Dr. Michael Brenner and Dr. David Lee before founding the Nigrovic laboratory in 2010.

Dr. Nigrovic also directs the NIAMS-funded Joint Biology Consortium arthritis research infrastructure. He is Co-Editor of Arthritis&Rheumatology and serves on the Scientific Advisory Board of the Arthritis National Research Foundation, as well as of the Rheumatology Research Foundation.  He was founding co-chair of the pediatric rheumatology mentoring program AMIGO.  He received the Young Mentor Award of Harvard Medical School in 2014, and was elected in 2018 to the American Society for Clinical Investigation (ASCI).

Lab Members

Title: Research Assistant
Lab member since 2018

2017 BRI Summer Research Intern from Bates College

Duke University Medical Student
Lab member since 2017

Publications and awards

Rheumatology Research Foundation Medical and Graduate Student Preceptorship entitled “Analyzing transitional care models in chronic illness: CAPRI.”

Title: Postdoctoral fellow
Lab member since 2015

Publications and awards

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis. J Clin Invest 2017 April 4 [ePub].

Lovejoy Resident Research Award, Boston Children’s Hospital, 2014 ($5,000)

American College of Rheumatology Resident Research Preceptorship, 2015 ($15,000)

American College of Rheumatology Pediatric Research Award, 2016

Pediatric Rheumatology Symposium Abstract Award , 2017

Title: Instructor in Medicine
Lab member since 2013

Publications and awards

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis. J Clin Invest 2017 April 4 [ePub].

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017 :blood-2017-03-768507; doi: https://doi.org/10.1182/blood-2017-03-768507 [online ahead of print]

Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.

Dellinger AL, Cunin P, Lee D, Kung AL, Brooks DB, Zhou Z, Nigrovic PA, Kepley CL. Inhibition of inflammatory arthritis using fullerene nanomaterials. PLoS One. 2015 Apr 16;10(4):e0126290. doi: 10.1371/journal.pone.0126290. eCollection 2015.

Society for Leukocyte Biology Travel Prize, Verona, Italy, 2016

Outstanding Abstract Presentation Award, Gordon Research Seminar, Barga, Italy, 2017

Title: Research Assistant
Lab member since 2018

Maya is contributing to research on resident memory T cells. Maya is from Wisconsin and graduated from Harvard College. Outside of lab, Maya is a student in molecular and cellular biology at Harvard (GSAS) and a Harvard Senior Common Room member of Lowell House.

Heidelberg University Medical Student

Lab member since 2016

Publications and awards

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017;130(19):2092-2100, doi: https://doi.org/10.1182/blood-2017-03-768507

Grieshaber-Bouyer R and Gerber C. Arthroscopic Repair of Recurrent Posterior Shoulder Subluxation after Total Shoulder Arthroplasty. JBJS Case Connect. 2017;7:e71. doi: https://doi.org/10.2106/JBJS.CC.17.00048

Boehringer Ingelheim Fonds MD Fellowship, 2016 (€19,200)

German National Academic Foundation, since 2012

Title: Instructor in Pediatrics
Lab member since 2010

Publications and awards

Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.

Henderson LA, Loring SH, Gill RR, Liao KP, Ishizawar R, Kim S, Perlmutter-Goldenson R, Rothman D, Son MB, Stoll ML, Zemel LS, Sandborg C, Dellaripa PF, Nigrovic PA. Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. J Rheumatol. 2013 Mar; 40(3):273-81.

Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Son MB, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Lee YN, Nigrovic PA, Notarangelo LD. Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul;68(7):1758-68.

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka C, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivaskiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S and Brenner MB. Pathologically expanded ‘peripheral’ B cell-helper T cells in rheumatoid arthritis. Nature 2017 Feb 1;542(7639):110-114.

Promotion to Instructor in Pediatrics, 2015

Rheumatology Research Foundation Scientist Development Award, 2014-2016 ($125,000)

Rheumatology Research Foundation Investigator Award, 2016-18 ($375,000)

Title: Coordinator
Lab member since 2016

Publications and awards

Current member of Nigrovic laboratory responsible for coordinating the development of NIAMS P30-funded Joint Biology Consortium. Her experimental studies focus on synovial T cells.

Title: Instructor in Pediatrics
Lab member since 2012

Publications and awards

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology [review]. J Leukoc Biol. 2013 Oct;94(4):585-94.

Lovejoy Resident Research Award, 6/2012 ($6,000)

Lovejoy Resident Research Award, 11/2012 ($5,000)

ACR Resident Research Preceptorship, 2012 ($15,000)

Boston Children’s Medical Staff Organization House Officer Development Award for Empirical Research ($5,000)

Boston Children’s Hospital Alumni Travel Award ($1,000)

Tobé and Stephen E. Malawista Award of the Rheumatology Research Foundation, 2014

Rheumatology Research Foundation Scientist Development Award, 2015-2017 ($125,000)

Marshall J. Schiff, MD Memorial Fellow Research Award, 2015

ACR Distinguished Fellow Award, 2016

Promotion to Instructor in Pediatrics, 2016

Rheumatology Research Foundation Investigator Award, 2017-19 ($375,000)

Title: Post doctoral fellow
Lab member since 2015

Publications and awards

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017 :blood-2017-03-768507; doi: https://doi.org/10.1182/blood-2017-03-768507 [online ahead of print]

Joint Biology Consortium Microgrant (2017, $5,000)

Pediatric Rheumatology Symposium Abstract Award , 2017

Title: Postdoctoral fellow
Lab member since 2016

Publications:

Martínez-Bonet, M., González-Serna, A., Clemente, M. I., Morón-López, S., Díaz, L., Navarro, M., et al. (2017). Relationship between CCR5(WT/Δ32) heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection. Clinical Microbiology and Infection, 23(5), 318-324.

Martínez-Bonet M, Palladino C, Briz V, Rudolph JM, Fackler OT, Relloso M, et al. (2015) A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. PLoS ONE 10(12): e0145239. https://doi.org/10.1371/journal.pone.0145239.

Martínez-Bonet, M., Isabel Clemente, M., Jesús Serramía, M., Muñoz, E., Moreno, S., & Ángeles Muñoz-Fernández, M. (2015). Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1. Scientific Reports5, 16445. http://doi.org/10.1038/srep16445.

Martínez-Bonet, M., Puertas, M. C., Fortuny, C., Ouchi, D., Mellado, M. J., Rojo, P., … Martinez-Picado, J. (2015). Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America61(7), 1169–1178. http://doi.org/10.1093/cid/civ456

Title: Postdoctoral fellow
Lab member since 2018

Dr. Qiang Wang is a postdoctoral research fellow at BWH under the supervision of Dr. Peter Nigrovic.   Dr. Wang received his Bachelor’s degree in Veterinary Medicine from Jilin University, China, followed by his Ph.D. degree at Tufts University.   

 

Former Lab Members

Research assistant

2012-2016

Publications and awards

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Accepted to the University of Massachusetts Medical School, 2016.

Postdoctoral fellow

2015-2017

Publications and awards

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017 :blood-2017-03-768507; doi: https://doi.org/10.1182/blood-2017-03-768507 [online ahead of print]

Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic insights into regulated cargo binding by ACAP1 protein. J Biol Chem. 2012 Aug 17;287(34):28675-85. doi: 10.1074/jbc.M112.378810. Epub 2012 May 29.

Hsu VW, Bai M, Li J. Getting active: protein sorting in endocytic recycling. Nat Rev Mol Cell Biol. 2012 Apr 13;13(5):323-8. doi: 10.1038/nrm3332. Review.

Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May;13(5):559-67. doi: 10.1038/ncb2221. Epub 2011 Apr 17.

Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30;178(3):453-64.

Title: Research Trainee/Intern
Lab member 2016-2017

Publications and awards

Research trainee visiting Nigrovic laboratory for one year.

Title: Harvard Masters in Immunology student
Lab member 2017-2018

Publications and awards

Masters student in Nigrovic laboratory to study experimental genetics.

Postdoctoral fellow

2010-2014

Publications and awards

Ercan A, Cui J, Hazen MM, Batliwalla F, Royle L, Rudd PM, Coblyn JS, Shadick N,  Weinblatt ME, Gregersen P, Lee DM, Nigrovic PA. Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 5; 14(2):R43.

Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.

Adamczyk B, Struwe WB, Ercan A, Nigrovic PA, Rudd PM. Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis. J Proteome Res. 2013 Jan 4;12(1):444-54.

Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G. Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. J Clin Invest. 2013 May 1;123(5):2183-92.

Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 1;23(11):2880-7.

Ercan A, Kohrt W, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, and Nigrovic PA.  Estrogens regulate glycosylation of immunoglobulin G in women and men. JCI Insight 2017;2:e89703.

Best Clinical/Translational Abstract Award (BWH Biomedical Research Institute, 2010)

Research Grant, Arthritis National Research Foundation, 2011-2013

Kelly Prize in JIA Research, ANRF, 2011 and 2012 ($150,000)

Research Grant, NIH Building Interdisciplinary Careers in Women’s Health Research (BIRCWH), 2012-2014 ($300,000)

BWH Best Musculoskeletal Research Paper prize 2012

Research assistant

2010-2012

Publications and awards

Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes.  PLOS ONE. 2012; 7(10):e47252.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Accepted to Medical School, 2012.

Title: Postdoctoral fellow
2016-2018

Publications and awards

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017 :blood-2017-03-768507; doi: https://doi.org/10.1182/blood-2017-03-768507 [online ahead of print]

Joint Biology Consortium Microgrant (2017, $5,000)

Postdoctoral fellow

2010

Publications and awards

Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes.  PLOS ONE. 2012; 7(10):e47252.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Title: Instructor of Medicine
Lab member 2013- 2018

Publications and awards

Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.

Promotion to Instructor in Medicine, Harvard Medical School, 2014

Kelly Prize in JIA Research, Arthritis National Research Foundation, 2015 and 2016

Research Grant, Arthritis National Research Foundation, 2015-2017 ($200,000)

Research Grant, National Multiple Sclerosis Society ($50,000)

NIH NINDS R21, 2016 ($275,000)

NIH NIAMS R21 ($275,000)

Title: 2017 Summer Research Student from Brandeis University

Research assistant

2014-2016

2017 Summer

Publications and awards

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Accepted to New York Medical College, 2016

Title: Research Assistant
2016-2018

Publications and awards

Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.

Current member of Nigrovic laboratory studying murine arthritis.

Postdoctoral fellow

2010-2012

Publications and awards

Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis. J Clin Invest 2017 [in press].

Research assistant

2010-2011

Publications and awards

Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes.  PLOS ONE. 2012; 7(10):e47252.

Wang J, Bair A, King S, Shnayder R, Hsieh YF, Shieh C-C, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a beta 2 integrin-dependent mechanism. Blood. 2012 Aug 16; 120(7):1489-98.

Cloutier N, Tan S, Boudreau LH, Cramb C, Subbaiah R, Lahey L, Albert A, Shnayder R, Gobezie R, Nigrovic PA, Farndale RW, Robinson WH, Brisson A, Lee DM, Boilard E. The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes. EMBO Mol Med. 2013 Feb; 5(2):235-49.

Accepted to Mount Sinai Medical School, 2016.

Instructor in Medicine

2010-2014

Publications and awards

Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017 :blood-2017-03-768507; doi: https://doi.org/10.1182/blood-2017-03-768507 [online ahead of print]

Wang J, Bair A, King S, Shnayder R, Hsieh YF, Shieh C-C, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a beta 2 integrin-dependent mechanism. Blood. 2012 Aug 16; 120(7):1489-98.

Kaieda S*, Wang JX*, Schnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes.  PLOS ONE. 2012; 7(10):e47252.

Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology [review]. J Leukoc Biol. 2013 Oct;94(4):585-94.281-6.

Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.

Research Grant, Arthritis National Research Foundation (2013-2015)

Promotion to Instructor in Medicine, Harvard Medical School, 2014

Title: Research Assistant to Dr. Gang Li.
Lab member 2016 -2018

Publications and awards

Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.

Nigrovic Lab 2017
Nigrovic Lab 2017